September 25, 2025
This interactive feature describes a 63-year-old woman who presented to the ED with a 1-month history of intractable and worsening nausea and vomiting. Test your diagnostic and therapeutic skills a...
Matthew A. Crane, Nicolette J. Rodriguez
September 25, 2025
Medical education in diagnosis that teaches about diagnostic inequities, equity considerations, and equitable diagnostic communication can lead to greater diagnostic equity.
Denise M. Connor, Cristina M. Gonzalez
September 25, 2025
The appropriate duration of anticoagulation for venous thromboembolism (VTE) in patients who have a transient provoking factor (e.g., surgery, trauma, or immobility) and concomitant enduring risk f...
Gregory Piazza, Samuel Z. Goldhaber
September 25, 2025
For decades, the guidance was simple: treat a provoked venous thromboembolism (VTE) — one caused by a transient factor such as surgery, trauma, or immobility — for 3 to 6 months, stop, and move on....
Neil A. Zakai
September 25, 2025
A 53-year-old man was evaluated because of severe left ventricular dysfunction with an apical aneurysm. Five and a half months earlier, the patient had had left middle cerebral artery stroke. A dia...
Garrick C. Stewart, Briana Castillo
September 25, 2025
In a patient with treatment-resistant ulcerative colitis, CD19 CAR T-cell therapy led to drug-free remission and mucosal healing, suggesting that B-cell targeting may offer a novel therapeutic pathway.
Fabian Müller, Markus F. Neurath
September 25, 2025
To the Editor: To better understand the results of the British Heart Foundation Randomized Trial of Routine Cerebral Embolic Protection in Transcatheter Aortic Valve Implantation (BHF PROTECT-TAVI)...
September 25, 2025
The therapeutic efficacy of the cardiac glycoside digitoxin in patients with heart failure and reduced ejection fraction is not established.In this international, double-blind, placebo-controlled t...
Udo Bavendiek, Johann Bauersachs
September 25, 2025
Cardiac glycosides are among the oldest medications in cardiovascular care, prized for their actions as positive inotropic agents and modulators of atrioventricular conduction. In heart failure wit...
Marc A. Pfeffer
September 25, 2025
A 15-year-old girl presented with a 2-week history of a painful, blistering rash on both hands. One week before the onset of symptoms, she had started oral doxycycline therapy to treat acne.
Grace Boyd, Carol Cheng
September 25, 2025
Even with the most reticent patients, Dr. Kolhouse somehow uncovered the things that mattered most to them, discovering each one’s unique definition of a good day — and offering them more of those.
Mark Earnest
September 25, 2025
Intravenous thrombolysis remains a standard treatment for acute ischemic stroke within 4.5 hours after onset. Vascular reocclusion may occur after intravenous thrombolysis and may be preventable wi...
